On the Self and Overthinking — A Thought for Inspiration
On the Self and Overthinking — A Thought for Inspiration
Conformational Coupling Across the Plasma Membrane in Activation of the EGF Receptor
Book Recommendation: Dynamics in Enzyme Catalysis
Rethinking Life as Protocol — A Philosophical Exploration
Book Recommendation: Molecular Driving Forces: Statistical Thermodynamics in Chemistry and Biology
Borderlands 3: pure chaos, solo fun
Gris & Neva: beautiful art!!
Multiple Diverse Ligands Binding at a Single Protein Site: A Matter of Pre-existing Populations
Behavior of Intrinsically Disordered Proteins (IDPs) in Protein-Protein Complexes: Emphasis on Fuzziness
Book Recommendation: Protein Actions: Principles and Modeling
It Takes Two — A Game We Played Together
Protein Isoelectric Point (pI) and Intracellular Localization: Relationships and Functional Insights
Water-Membrane Partition Thermodynamics of an Amphiphilic Lipopeptide: An Enthalpy-Driven Hydrophobic Effect
Why Are ‘Natively Unfolded’ Proteins Unstructured Under Physiologic Conditions
Preformed Structural Elements Feature in Partner Recognition by Intrinsically Unstructured Proteins
how to define dilute & semi dilute & high salt concentrations etc
native & recombinant proteins
Structural Characteristics of Protein Binding Sites for Calcium and Lanthanide Ions
Conformations of Intrinsically Disordered Proteins Are Influenced by Linear Sequence Distributions of Oppositely Charged Residues
Diversity of Conformational States and Changes within the EF-hand Protein Superfamily
Net Charge Per Residue Modulates Conformational Ensembles of Intrinsically Disordered Proteins
Structural Basis for Diversity of the EF-hand Calcium-binding Proteins
Structures and Metal-ion Binding Properties of the Ca2+-Binding Helix–Loop–Helix EF-hand Motifs
Pinning Down Proline-Directed Phosphorylation Signaling
Anchor Residues in Protein–Protein Interactions
Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity
The Hallmark of AGC Kinase Functional Divergence is Its C-terminal Tail, a Cis-acting Regulatory Module
Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and Upon Multisite Phosphorylation
Water and Molecular Chaperones as Weak Links in Protein Folding Networks: A Game Theory View of Protein Folding
The Changing Landscape of Protein Allostery: Dynamic Ensembles and Functional Shifts
Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein
Network Topology of a Potential Energy Landscape: A Static Scale-Free Network
Summer — My Sweet Little Monster
An Inherent Difference Between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation
Architecture and Membrane Interaction of the EGF Receptor
Conformational Coupling Across the Plasma Membrane in Activation of the EGF Receptor
Network Protocols vs. Biological Protocols — Advanced Parallels
Detroit: Become Human — A Game About Choices and Humanity
Algorithms and Biological Behavior
Data Structures and Biological Architecture
System Layer — Protocols for Organism-Wide Coordination
Network Layer — How Cells Resolve Conflicting Signals
Protocol Layers in Biology — From Molecules to Systems
Cellular Layer — How Cells Negotiate and Confirm Signals
Evolutionarily Conserved Networks of Residues Mediate Allosteric Communication in Proteins
Molecular Layer — How Proteins Negotiate
Identification of the Autophosphorylation Sites in Rhodopsin Kinase
Binding Mechanism of Intrinsically Disordered Proteins: Theory, Simulation, and Experiment
Induced Fit, Conformational Selection, and Independent Dynamic Segments: An Extended View of Binding Events
Molecular Mechanism Underlying Ca²⁺/Calmodulin Dependent Protein Kinase Kinase (CaMKK) Signal Transduction
DFGmodel: Predicting Protein Kinase Structure in Inactive States for Structure-based Discovery of Type-II Inhibitors
Regulation of Protein Kinases: Activation Segment Conformation and Functional Control
Regulatory Modules: Coupling Protein Stability to Phosphorylation during Cell Division
Protein Grabs a Ligand by Extending Anchor Residues: Ca²⁺ Binding Mechanism of Calmodulin
Protein Interaction Kinetics Delimit Phosphorylation-Driven Protein Switches
Strong Links Are Important, but Weak Links Stabilize Them — The Role of Weak Links in Complex Systems
Surface Comparison Reveals Conserved Activation Mechanism in Protein Kinases
Community Analysis of PKA: A Dynamic View of Kinase Architecture
Graded Enhancement of p53-CBP Interaction by Multisite Phosphorylation
Protein Kinases: Evolution of Dynamic Regulatory Proteins
The Conformational Plasticity of Protein Kinases
F-Helix as a Structural Scaffold for Active Protein Kinase Assembly
YOU FOUND RRDD’s pic ⸝⸝•‧̫•⸝⸝
AKAP Signaling Complexes: Focal Points in Space and Time
CASK Functions as a Mg²⁺-Independent Neurexin Kinase
Intrinsically Disordered Regions Are Poised to Act as Sensors of Cellular Chemistry
Single-Molecule Spectroscopy Reveals Polymer Effects of Disordered Proteins in Crowded Environments
Structural Biases in Disordered Proteins Are Prevalent in the Cell
Revealing the Hidden Sensitivity of Intrinsically Disordered Proteins to Their Chemical Environments
Homing In: Mechanisms of Substrate Targeting by Protein Kinases
Structures of Two Repeats of Spectrin Suggest Models of Flexibility
SOCKET: A Program for Identifying and Analyzing Coiled-Coil Motifs within Protein Structures
Principles of Helix-Helix Packing in Proteins: The Helical Lattice Superposition Model
Structure-Function of the Multifunctional Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)
Phosphoproteomics of the Arabidopsis Plasma Membrane and a New Phosphorylation Site Database
Autophosphorylation: A Salient Feature of Protein Kinases
Structural Evidence for Loose Linkage Between Ligand Binding and Kinase Activation in EGFR
Molecular Evolution of CDPKs in Plants and Protists: The Role of Ancestral Introns
A Temporary Gating of Actin Remodeling during Synaptic Plasticity: Interplay between the Kinase and Structural Functions of CaMKII
Assembly of Allosteric Macromolecular Switches: Lessons from PKA
Activation of the Essential Kinase PDK1 by Phosphoinositide-Driven Trans-Autophosphorylation
Ile441 Is Essential for Autoinhibition of CaMKK: Regulatory Mechanism of Ca2+/Calmodulin-Dependent Protein Kinase Kinase
Decoding Ca²⁺ Signals Through Plant Protein Kinases
Mechanism of CDK Activation Revealed by the Structure of a CyclinA-CDK2 Complex
Variable Calcium Sensitivity in Arabidopsis CDPKs: Activated or Not by Calcium?
How Do Kinases Transfer Phosphoryl Groups
Structure of the Autoinhibited CaMKII Kinase Domain and SAXS Analysis of the Holoenzyme
A Mechanism for Tunable Autoinhibition in the Structure of Human CaMKII Holoenzyme
αKAP as an Anchoring Protein for a Novel CaMKII Isoform in Skeletal Muscle
Regulation of the ABC Kinases by Phosphorylation: Protein Kinase C as a Paradigm
Allosteric Activation of Toxoplasma CDPK1: A Splint Model for Kinase Regulation
Structural Insights into Apicomplexan CDPK Activation: A Calcium-Triggered Mechanism
The CaMKII Holoenzyme Structure in Activation-Competent Conformation
Membrane Binding of Recoverin: From Mechanistic Understanding to Biological Functionality
Unique Conformational Adaptation of Calmodulin to CaMKK: A Distinct Mode of Calcium-Dependent Kinase Regulation
Autonomous Activity of CaMKKβ via Intramolecular Autophosphorylation at Thr482: A Mechanism to Bypass Calcium-Calmodulin Dependency
Target-Induced Conformational Adaptation of Calmodulin in Complex with Nematode CaMKK Peptide: Insights into Calcium-Dependent Kinase Regulation
The Calmodulin-Fused Kinase (CFK) Family: A Major System Converting Calcium Signals into Protein Phosphorylation in Plants
Common Activation Mechanism in CDPK: Structural Insights into CAD Refolding
N-terminal Domain of CDPK1 Determines Substrate Specificity: A Key to Rewiring Kinase Signaling
Prediction of EF-hand-like Calcium Binding Regions in Myosin Light Chain and T4 Lysozyme
Comparative Modeling Studies of the Calmodulin-like Domain of CDPK from Soybean
Discovery of Calcium-Dependent Protein Kinase (CDPK) as a Calmodulin-like Kinase Family
Real-Time Imaging of CDPK Conformational Changes Reveals Calcium-Decoding Mechanisms in Planta
Calmodulin Trapping by CaMKII: A Mechanism for Frequency Decoding of Calcium Signals
Structure of the Regulatory Apparatus of a Calcium-Dependent Protein Kinase (CDPK): A Novel Mode of Calmodulin-Target Recognition
Dual Role of Calmodulin in CaMKII Autophosphorylation: Decoding Calcium Frequency
Evidence for Differing Roles for Each Lobe of the Calmodulin-like Domain in a Calcium-dependent Protein Kinase
Unexpected Structure of the Ca2+-Regulatory Region from Soybean Calcium-dependent Protein Kinase-Alpha
Activation of a Ca2+-dependent Protein Kinase Involves Intramolecular Binding of a Calmodulin-like Regulatory Domain
Membrane Localization of a Rice Calcium-Dependent Protein Kinase (CDPK) Is Mediated by Myristoylation and Palmitoylation
Tobacco Calcium-Dependent Protein Kinases Are Differentially Phosphorylated In Vivo as Part of a Kinase Cascade That Regulates Stress Response
Autophosphorylation-Dependent Activation of a Calcium-Dependent Protein Kinase from Groundnut
Histidine Protein Kinases: Key Signal Transducers Outside the Animal Kingdom
Predicting Coiled-Coil from Protein Sequences: A 1991 Science Classic
KALRN: A Central Regulator of Synaptic Function and Synaptopathies (Gene, 2021)
Rapid Whole Cell Imaging Reveals a Calcium-APPL1-Dynein Nexus that Regulates Cohort Trafficking of Stimulated EGF Receptors
A Critical Evolution of Protein Kinase Regulation by Activation Loop Autophosphorylation
Kinetic and Catalytic Mechanisms of Protein Kinases
Little Nightmares — A Dark Fairy Tale You Don’t Forget
Crusader Kings III: Where History Meets Chaos — A Personal Journey
Systems We Build, Systems We Are
What Would a Biological Protocol Look Like?
Hades — A Roguelike That Feels Personal
