Notes on 2014 Cell paper that identifies the ‘DFG+1’ residue as a key determinant of Ser/Thr kinase phosphoacceptor specificity, with structural and biochemical validation.
Notes on 2014 Cell paper that identifies the ‘DFG+1’ residue as a key determinant of Ser/Thr kinase phosphoacceptor specificity, with structural and biochemical validation.
An elegant dissection of how the C-terminal tail (C-tail) in AGC kinases serves as a cis-acting regulatory module, driving functional divergence from other kinase families. Through conserved interactions and structural specialization, the C-tail orchestrates key regulatory processes, acting as a unique hallmark of AGC kinases.
An elegant dissection of how the C-terminal tail (C-tail) in AGC kinases serves as a cis-acting regulatory module, driving functional divergence from other kinase families. Through conserved interactions and structural specialization, the C-tail orchestrates key regulatory processes, acting as a unique hallmark of AGC kinases.
An in-depth study of EGFR activation focusing on transmembrane and juxtamembrane coupling, density-dependent activation, and the role of the plasma membrane in maintaining autoinhibition.
An in-depth study of EGFR activation focusing on transmembrane and juxtamembrane coupling, density-dependent activation, and the role of the plasma membrane in maintaining autoinhibition.
Notes on 2014 ACS paper introducing DFGmodel, a computational approach to predict kinase inactive structures for type-II inhibitor discovery. Includes insights on DFG-flip and kinase conformational analysis.
Notes on 2014 ACS paper introducing DFGmodel, a computational approach to predict kinase inactive structures for type-II inhibitor discovery. Includes insights on DFG-flip and kinase conformational analysis.
Notes on 2004 Molecular Cell review analyzing how activation segment conformation regulates protein kinase activity, including insights into RD pocket, anchor residues, and alternative activation mechanisms.
Notes on 2004 Molecular Cell review analyzing how activation segment conformation regulates protein kinase activity, including insights into RD pocket, anchor residues, and alternative activation mechanisms.
Notes on 2006_PNAS paper exploring conserved structural mechanisms of kinase activation via surface comparison.
Notes on 2010 Cell Review article exploring the structural and evolutionary principles that shape the dynamic regulatory mechanisms of protein kinases.
Notes on 2010 Cell Review article exploring the structural and evolutionary principles that shape the dynamic regulatory mechanisms of protein kinases.
Notes on 2002 Cell review discussing conformational plasticity of protein kinases, highlighting key structural elements, activation mechanisms, and pseudosubstrate regulation. Includes insights on αC helix, activation loop, and therapeutic implications (e.g., Gleevec binding).
Notes on 2002 Cell review discussing conformational plasticity of protein kinases, highlighting key structural elements, activation mechanisms, and pseudosubstrate regulation. Includes insights on αC helix, activation loop, and therapeutic implications (e.g., Gleevec binding).
