Notes on 2004 PNAS paper introducing the concept of anchor residues as key pre-configured side chains that drive protein–protein interactions. The study highlights a two-step binding mechanism, combining preformed ‘anchor’ interactions and induced-fit adjustments.
Notes on 2004 PNAS paper introducing the concept of anchor residues as key pre-configured side chains that drive protein–protein interactions. The study highlights a two-step binding mechanism, combining preformed ‘anchor’ interactions and induced-fit adjustments.
Notes on a landmark 1998 EMBO paper identifying αKAP as the first anchoring protein for CaM kinase II, revealing how αKAP targets CaMKII to the sarcoplasmic reticulum in skeletal muscle and enables tissue-specific membrane localization and signaling control.
Notes on a landmark 1998 EMBO paper identifying αKAP as the first anchoring protein for CaM kinase II, revealing how αKAP targets CaMKII to the sarcoplasmic reticulum in skeletal muscle and enables tissue-specific membrane localization and signaling control.
