Common Activation Mechanism in CDPK: Structural Insights into CAD Refolding

Note on the detailed structural study of CDPK activation, focusing on apicomplexan CAD conformations (CpCDPK, PfCDPK3), offering new insight into a potentially universal activation mechanism for CDPKs.

Prediction of EF-hand-like Calcium Binding Regions in Myosin Light Chain and T4 Lysozyme

A 1975 Science paper pioneering the computational prediction of EF-hand calcium-binding motifs in unexpected proteins, revealing evolutionary insights into calcium sensor domains and highlighting structural conservation even in non-calcium-binding proteins.

Prediction of EF-hand-like Calcium Binding Regions in Myosin Light Chain and T4 Lysozyme

A 1975 Science paper pioneering the computational prediction of EF-hand calcium-binding motifs in unexpected proteins, revealing evolutionary insights into calcium sensor domains and highlighting structural conservation even in non-calcium-binding proteins.

Unexpected Structure of the Ca2+-Regulatory Region from Soybean Calcium-dependent Protein Kinase-Alpha

Notes on a 2004 JBC paper uncovering the high-resolution structure of the Ca2+-regulatory domain of soybean CDPK-alpha, revealing novel lobe interactions and a pivot-based mechanism, distinct from calmodulin-based models.

Unexpected Structure of the Ca2+-Regulatory Region from Soybean Calcium-dependent Protein Kinase-Alpha

Notes on a 2004 JBC paper uncovering the high-resolution structure of the Ca2+-regulatory domain of soybean CDPK-alpha, revealing novel lobe interactions and a pivot-based mechanism, distinct from calmodulin-based models.

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