Autonomous Activity of CaMKKβ via Intramolecular Autophosphorylation at Thr482: A Mechanism to Bypass Calcium-Calmodulin Dependency
Notes on a 2011 ACS Biochemistry study showing that CaMKKβ, unlike CaMKKα, achieves high autonomous activity via intramolecular autophosphorylation at Thr482, partially releasing itself from autoinhibition and making it Ca2+/CaM-independent — revealing a unique kinase regulation mechanism within the CaMKK family.
