Notes on 2014 Cell paper that identifies the ‘DFG+1’ residue as a key determinant of Ser/Thr kinase phosphoacceptor specificity, with structural and biochemical validation.
Notes on 2014 Cell paper that identifies the ‘DFG+1’ residue as a key determinant of Ser/Thr kinase phosphoacceptor specificity, with structural and biochemical validation.
Notes on 1998 Cell review discussing kinase phosphoryl transfer mechanisms, conformational dynamics, cofactor roles, and binding motifs. Highlights the debate between associative (SN2) and dissociative (SN1) pathways, with structural evidence for both models.
Notes on 1998 Cell review discussing kinase phosphoryl transfer mechanisms, conformational dynamics, cofactor roles, and binding motifs. Highlights the debate between associative (SN2) and dissociative (SN1) pathways, with structural evidence for both models.
Comprehensive notes on the 2001 Chemical Reviews paper exploring the catalytic and kinetic mechanisms of protein kinases, with PKA as a model system. Covers substrate recognition, metal ion roles, phosphoryl transfer mechanisms, activation loop function, and rate-determining steps.
Comprehensive notes on the 2001 Chemical Reviews paper exploring the catalytic and kinetic mechanisms of protein kinases, with PKA as a model system. Covers substrate recognition, metal ion roles, phosphoryl transfer mechanisms, activation loop function, and rate-determining steps.
