Note on the discovery that the variable N-terminal domain of CDPK1 controls substrate specificity—offering a new mechanism to engineer signaling specificity in plants.
A 2000 PROTEINS paper exploring the structural modeling of the calmodulin-like domain (CLD) of soybean CDPK-α, revealing unique domain features and potential intramolecular regulatory mechanisms based on homology modeling and experimental validation.
A 2000 PROTEINS paper exploring the structural modeling of the calmodulin-like domain (CLD) of soybean CDPK-α, revealing unique domain features and potential intramolecular regulatory mechanisms based on homology modeling and experimental validation.
A 1991 Science paper reporting the discovery of a soybean CDPK as a novel class of calcium-dependent kinases, providing structural and evolutionary insights that shaped the understanding of CDPKs as CaM-like autonomous calcium sensors.
A 1991 Science paper reporting the discovery of a soybean CDPK as a novel class of calcium-dependent kinases, providing structural and evolutionary insights that shaped the understanding of CDPKs as CaM-like autonomous calcium sensors.
Notes on a 2023 The Plant Cell study that introduces a genetically encoded FRET-based biosensor to monitor real-time conformational changes of CDPKs (CPKs) in response to calcium signals in vivo, highlighting distinct calcium sensitivities of CPK21 and CPK23 in stress responses.
Notes on a 2023 The Plant Cell study that introduces a genetically encoded FRET-based biosensor to monitor real-time conformational changes of CDPKs (CPKs) in response to calcium signals in vivo, highlighting distinct calcium sensitivities of CPK21 and CPK23 in stress responses.
A 2006 JMB study presenting the crystal structure of Arabidopsis CDPK’s regulatory domain, revealing a domain-swapped dimer and an unexpected mechanism of calmodulin-like domain (CaM-LD) recognition, challenging classical calmodulin-target models.
A 2006 JMB study presenting the crystal structure of Arabidopsis CDPK’s regulatory domain, revealing a domain-swapped dimer and an unexpected mechanism of calmodulin-like domain (CaM-LD) recognition, challenging classical calmodulin-target models.
Note on the seminal 1994 paper unveiling calmodulin’s dual role in CaMKII autophosphorylation and proposing a model for calcium frequency decoding in neurons. Includes reflections on CDPK parallels and a comparative framework for calcium signaling kinases.
Note on the seminal 1994 paper unveiling calmodulin’s dual role in CaMKII autophosphorylation and proposing a model for calcium frequency decoding in neurons. Includes reflections on CDPK parallels and a comparative framework for calcium signaling kinases.
Notes on a 2004 JBC paper exploring differential roles of N- and C-lobes in the CaM-like domain (CaM-LD) of CDPK, uncovering distinct Ca2+ affinities and their role in regulating kinase activation through interactions with the junction domain.
Notes on a 2004 JBC paper exploring differential roles of N- and C-lobes in the CaM-like domain (CaM-LD) of CDPK, uncovering distinct Ca2+ affinities and their role in regulating kinase activation through interactions with the junction domain.
Notes on a 2004 JBC paper uncovering the high-resolution structure of the Ca2+-regulatory domain of soybean CDPK-alpha, revealing novel lobe interactions and a pivot-based mechanism, distinct from calmodulin-based models.
Notes on a 2004 JBC paper uncovering the high-resolution structure of the Ca2+-regulatory domain of soybean CDPK-alpha, revealing novel lobe interactions and a pivot-based mechanism, distinct from calmodulin-based models.
