Notes on the 1999 Cell paper describing crystal structures of spectrin repeats and introducing two models for spectrin’s flexibility: conformational rearrangement and linker bending. Provides insights into spectrin’s role as a flexible cytoskeletal scaffold.
Notes on the 1999 Cell paper describing crystal structures of spectrin repeats and introducing two models for spectrin’s flexibility: conformational rearrangement and linker bending. Provides insights into spectrin’s role as a flexible cytoskeletal scaffold.
Notes on the 2001 JMB paper introducing SOCKET, a computational tool that identifies coiled-coil motifs based on structural features rather than sequence patterns. Highlights the diversity of coiled-coil structures, the central role of knobs-into-holes packing, and applications in structural analysis and design.
Notes on the 2001 JMB paper introducing SOCKET, a computational tool that identifies coiled-coil motifs based on structural features rather than sequence patterns. Highlights the diversity of coiled-coil structures, the central role of knobs-into-holes packing, and applications in structural analysis and design.
Notes on a 2005 Cell paper revealing the crystal structure of autoinhibited CaMKII kinase domain and small-angle X-ray scattering (SAXS) analysis of the full holoenzyme, uncovering mechanisms for tight autoinhibition and explaining frequency-dependent activation.
Notes on a 2005 Cell paper revealing the crystal structure of autoinhibited CaMKII kinase domain and small-angle X-ray scattering (SAXS) analysis of the full holoenzyme, uncovering mechanisms for tight autoinhibition and explaining frequency-dependent activation.
Notes on the foundational 1991 Science paper introducing a sequence-based method to predict coiled-coil domains. This paper outlines a statistical framework using heptad repeat patterns, Gaussian distributions, and sliding windows, uncovering over 200 proteins in GenBank with potential coiled-coil motifs.
Notes on the foundational 1991 Science paper introducing a sequence-based method to predict coiled-coil domains. This paper outlines a statistical framework using heptad repeat patterns, Gaussian distributions, and sliding windows, uncovering over 200 proteins in GenBank with potential coiled-coil motifs.
