Notes on 2002 Protein Science review on how proteins with specificity bind multiple diverse ligands through pre-existing conformational populations and hinge-bending motions.
Notes on 2002 Protein Science review on how proteins with specificity bind multiple diverse ligands through pre-existing conformational populations and hinge-bending motions.
Notes on 2008 Biophysical Journal paper analyzing the thermodynamics of membrane insertion for an H-ras lipopeptide anchor (ANCH), highlighting the role of enthalpy-driven hydrophobic effects and conformational selection.
Notes on 2008 Biophysical Journal paper analyzing the thermodynamics of membrane insertion for an H-ras lipopeptide anchor (ANCH), highlighting the role of enthalpy-driven hydrophobic effects and conformational selection.
Notes on a 1999 Proteins review analyzing the conformational diversity of EF-hand motifs in calcium-binding proteins. Introduces Vector Geometry Mapping (VGM) to dissect helix movements beyond simple interhelical angles, and discusses functional implications of EF-hand plasticity.
Notes on a 1999 Proteins review analyzing the conformational diversity of EF-hand motifs in calcium-binding proteins. Introduces Vector Geometry Mapping (VGM) to dissect helix movements beyond simple interhelical angles, and discusses functional implications of EF-hand plasticity.
Notes on 2006 JMB review detailing EF-hand protein diversity, mechanisms of Ca2+ binding, and conformational change. Highlights the EFbeta-scaffold model and structural determinants of domain opening in calcium-binding proteins.
Notes on 2006 JMB review detailing EF-hand protein diversity, mechanisms of Ca2+ binding, and conformational change. Highlights the EFbeta-scaffold model and structural determinants of domain opening in calcium-binding proteins.
Notes on 2007 Biochemical Journal review discussing EF-hand structural diversity, Ca²⁺/Mg²⁺ binding properties, cooperativity, and conformational changes. Focus on EF-hand pairing, metal selectivity, and functional adaptation for signaling.
Notes on 2007 Biochemical Journal review discussing EF-hand structural diversity, Ca²⁺/Mg²⁺ binding properties, cooperativity, and conformational changes. Focus on EF-hand pairing, metal selectivity, and functional adaptation for signaling.
Notes on a 2002 Trends in Cell Biology review introducing phosphorylation-specific prolyl isomerization as a novel signaling mechanism. Pin1-mediated cis-trans switching of pSer/Thr-Pro motifs acts as a conformational timer for cellular signaling, impacting activity, interactions, and localization of key regulatory proteins.
Notes on a 2002 Trends in Cell Biology review introducing phosphorylation-specific prolyl isomerization as a novel signaling mechanism. Pin1-mediated cis-trans switching of pSer/Thr-Pro motifs acts as a conformational timer for cellular signaling, impacting activity, interactions, and localization of key regulatory proteins.
A groundbreaking exploration of how sequence patterning, especially proline and charge distributions, governs the conformational behavior of intrinsically disordered regions (IDRs) even under multisite phosphorylation, with compensatory conformational changes maintaining overall dimensions.
A groundbreaking exploration of how sequence patterning, especially proline and charge distributions, governs the conformational behavior of intrinsically disordered regions (IDRs) even under multisite phosphorylation, with compensatory conformational changes maintaining overall dimensions.
A groundbreaking study connecting protein folding energy landscapes to functional conformational changes in signaling proteins, showing how transient, non-native hydrogen bonds lower transition barriers and facilitate activation without unfolding.
