Notes on 2014 Cell paper that identifies the ‘DFG+1’ residue as a key determinant of Ser/Thr kinase phosphoacceptor specificity, with structural and biochemical validation.
Notes on 2014 Cell paper that identifies the ‘DFG+1’ residue as a key determinant of Ser/Thr kinase phosphoacceptor specificity, with structural and biochemical validation.
Notes on a 2014 PNAS paper analyzing PKA dynamics through community analysis.
The study redefines CASK as an active Mg²⁺-independent kinase that phosphorylates neurexin, integrating scaffolding and enzymatic functions, challenging its previous classification as a pseudokinase.
The study redefines CASK as an active Mg²⁺-independent kinase that phosphorylates neurexin, integrating scaffolding and enzymatic functions, challenging its previous classification as a pseudokinase.
