Notes on a 2001 JBIC review comparing structural features of Ca2+ and lanthanide-binding sites in proteins. Discusses coordination geometries, ligand types, and structural classes of metal-binding motifs, including under-representation of EF-hand in structural databases.
Notes on a 2001 JBIC review comparing structural features of Ca2+ and lanthanide-binding sites in proteins. Discusses coordination geometries, ligand types, and structural classes of metal-binding motifs, including under-representation of EF-hand in structural databases.
Notes on a 1999 Proteins review analyzing the conformational diversity of EF-hand motifs in calcium-binding proteins. Introduces Vector Geometry Mapping (VGM) to dissect helix movements beyond simple interhelical angles, and discusses functional implications of EF-hand plasticity.
Notes on a 1999 Proteins review analyzing the conformational diversity of EF-hand motifs in calcium-binding proteins. Introduces Vector Geometry Mapping (VGM) to dissect helix movements beyond simple interhelical angles, and discusses functional implications of EF-hand plasticity.
Notes on 2006 JMB review detailing EF-hand protein diversity, mechanisms of Ca2+ binding, and conformational change. Highlights the EFbeta-scaffold model and structural determinants of domain opening in calcium-binding proteins.
Notes on 2006 JMB review detailing EF-hand protein diversity, mechanisms of Ca2+ binding, and conformational change. Highlights the EFbeta-scaffold model and structural determinants of domain opening in calcium-binding proteins.
Notes on 2007 Biochemical Journal review discussing EF-hand structural diversity, Ca²⁺/Mg²⁺ binding properties, cooperativity, and conformational changes. Focus on EF-hand pairing, metal selectivity, and functional adaptation for signaling.
Notes on 2007 Biochemical Journal review discussing EF-hand structural diversity, Ca²⁺/Mg²⁺ binding properties, cooperativity, and conformational changes. Focus on EF-hand pairing, metal selectivity, and functional adaptation for signaling.
Notes on 2005 Biophysical Journal article analyzing atomistic pathways of Ca²⁺ binding to calmodulin, highlighting stepwise binding, dehydration coupling, and residue dynamics.
Notes on 2005 Biophysical Journal article analyzing atomistic pathways of Ca²⁺ binding to calmodulin, highlighting stepwise binding, dehydration coupling, and residue dynamics.
Overview of the plant-specific CDPK-SnRK superfamily, including CDPKs, CRKs, CCaMKs, SnRKs, and their Ca²⁺ regulatory mechanisms. Models of activation and functional diversity of Ca²⁺ decoding mechanisms are discussed.
Overview of the plant-specific CDPK-SnRK superfamily, including CDPKs, CRKs, CCaMKs, SnRKs, and their Ca²⁺ regulatory mechanisms. Models of activation and functional diversity of Ca²⁺ decoding mechanisms are discussed.
Note on the differential calcium sensitivity among Arabidopsis CDPK isoforms, highlighting the diversity of activation mechanisms and implications for calcium signaling in plants.
Note on the differential calcium sensitivity among Arabidopsis CDPK isoforms, highlighting the diversity of activation mechanisms and implications for calcium signaling in plants.
A fascinating study revealing that TgCDPK1 is stabilized and activated via an allosteric mechanism involving its regulatory CAD domain, challenging classical models of calcium-dependent kinase activation.
