Notes on a 2003 Nature Structural Biology paper introducing the concept of evolutionarily conserved residue networks that mediate allosteric communication. Using sequence-based statistical coupling analysis (SCA), the authors map sparse, functionally critical networks in GPCRs, proteases, and hemoglobins, highlighting a fundamental mechanism of long-range communication in protein structures.
Notes on a 2003 Nature Structural Biology paper introducing the concept of evolutionarily conserved residue networks that mediate allosteric communication. Using sequence-based statistical coupling analysis (SCA), the authors map sparse, functionally critical networks in GPCRs, proteases, and hemoglobins, highlighting a fundamental mechanism of long-range communication in protein structures.
Note on the evolutionary insights of CDPKs and CRKs through intron/exon analysis, proposing a monophyletic origin and highlighting the role of ancient intron-mediated gene fusion in the origin of CDPKs.
Note on the evolutionary insights of CDPKs and CRKs through intron/exon analysis, proposing a monophyletic origin and highlighting the role of ancient intron-mediated gene fusion in the origin of CDPKs.
Notes on a 2017 Scientific Reports study proposing the Calmodulin-Fused Kinase (CFK) family as the principal system for converting calcium signals to protein phosphorylation responses in plants, based on deep phylogenetic analysis tracing their evolutionary origins and functional diversification.
Notes on a 2017 Scientific Reports study proposing the Calmodulin-Fused Kinase (CFK) family as the principal system for converting calcium signals to protein phosphorylation responses in plants, based on deep phylogenetic analysis tracing their evolutionary origins and functional diversification.
A 1975 Science paper pioneering the computational prediction of EF-hand calcium-binding motifs in unexpected proteins, revealing evolutionary insights into calcium sensor domains and highlighting structural conservation even in non-calcium-binding proteins.
A 1975 Science paper pioneering the computational prediction of EF-hand calcium-binding motifs in unexpected proteins, revealing evolutionary insights into calcium sensor domains and highlighting structural conservation even in non-calcium-binding proteins.
A 1991 Science paper reporting the discovery of a soybean CDPK as a novel class of calcium-dependent kinases, providing structural and evolutionary insights that shaped the understanding of CDPKs as CaM-like autonomous calcium sensors.
A 1991 Science paper reporting the discovery of a soybean CDPK as a novel class of calcium-dependent kinases, providing structural and evolutionary insights that shaped the understanding of CDPKs as CaM-like autonomous calcium sensors.
