Helix

Notes on 2010 Cell Review article exploring the structural and evolutionary principles that shape the dynamic regulatory mechanisms of protein kinases.

Notes on 2010 Cell Review article exploring the structural and evolutionary principles that shape the dynamic regulatory mechanisms of protein kinases.

Notes on 2008_PNAS paper revealing F-helix as a hub for regulatory and catalytic spine anchoring in protein kinases.

Notes on 2008_PNAS paper revealing F-helix as a hub for regulatory and catalytic spine anchoring in protein kinases.

Notes on the 2001 JMB paper introducing SOCKET, a computational tool that identifies coiled-coil motifs based on structural features rather than sequence patterns. Highlights the diversity of coiled-coil structures, the central role of knobs-into-holes packing, and applications in structural analysis and design.

Notes on the 2001 JMB paper introducing SOCKET, a computational tool that identifies coiled-coil motifs based on structural features rather than sequence patterns. Highlights the diversity of coiled-coil structures, the central role of knobs-into-holes packing, and applications in structural analysis and design.

Notes on the 1996 JMB paper introducing the Helical Lattice Superposition Model for analyzing helix-helix packing geometry in proteins. Explores mathematical formulations of optimal packing angles, comparing ‘knobs into holes’ and ‘ridges into grooves’ models, and provides insights into amino acid preferences and packing flexibility.

Notes on the 1996 JMB paper introducing the Helical Lattice Superposition Model for analyzing helix-helix packing geometry in proteins. Explores mathematical formulations of optimal packing angles, comparing ‘knobs into holes’ and ‘ridges into grooves’ models, and provides insights into amino acid preferences and packing flexibility.

Notes on a 1995 Nature paper revealing the structural mechanism of CDK2 activation by cyclinA, focusing on key conformational changes that relieve autoinhibition and organize the catalytic site.

Notes on a 1995 Nature paper revealing the structural mechanism of CDK2 activation by cyclinA, focusing on key conformational changes that relieve autoinhibition and organize the catalytic site.

Notes on a 2004 JBC paper uncovering the high-resolution structure of the Ca2+-regulatory domain of soybean CDPK-alpha, revealing novel lobe interactions and a pivot-based mechanism, distinct from calmodulin-based models.

Notes on a 2004 JBC paper uncovering the high-resolution structure of the Ca2+-regulatory domain of soybean CDPK-alpha, revealing novel lobe interactions and a pivot-based mechanism, distinct from calmodulin-based models.

Notes on the foundational 1991 Science paper introducing a sequence-based method to predict coiled-coil domains. This paper outlines a statistical framework using heptad repeat patterns, Gaussian distributions, and sliding windows, uncovering over 200 proteins in GenBank with potential coiled-coil motifs.

Notes on the foundational 1991 Science paper introducing a sequence-based method to predict coiled-coil domains. This paper outlines a statistical framework using heptad repeat patterns, Gaussian distributions, and sliding windows, uncovering over 200 proteins in GenBank with potential coiled-coil motifs.