Notes on a 2017 Nature Communications paper revealing the 3D structure of the CaMKII holoenzyme in an activation-competent conformation, emphasizing the role of flexible linkers and dimeric kinase domain interactions in regulating activation and frequency decoding.
Notes on a 2017 Nature Communications paper revealing the 3D structure of the CaMKII holoenzyme in an activation-competent conformation, emphasizing the role of flexible linkers and dimeric kinase domain interactions in regulating activation and frequency decoding.
A comprehensive study unraveling the molecular dynamics of recoverin’s membrane binding via its calcium-dependent myristoyl switch, highlighting the importance of N-terminal domain conformations and transient C-terminal interactions.
A comprehensive study unraveling the molecular dynamics of recoverin’s membrane binding via its calcium-dependent myristoyl switch, highlighting the importance of N-terminal domain conformations and transient C-terminal interactions.
Note on the discovery that the variable N-terminal domain of CDPK1 controls substrate specificity—offering a new mechanism to engineer signaling specificity in plants.
Note on the discovery that the variable N-terminal domain of CDPK1 controls substrate specificity—offering a new mechanism to engineer signaling specificity in plants.
