Kinase

Notes on a 2014 PNAS paper analyzing PKA dynamics through community analysis.

Notes on 2010 Cell Review article exploring the structural and evolutionary principles that shape the dynamic regulatory mechanisms of protein kinases.

Notes on 2010 Cell Review article exploring the structural and evolutionary principles that shape the dynamic regulatory mechanisms of protein kinases.

Notes on 2002 Cell review discussing conformational plasticity of protein kinases, highlighting key structural elements, activation mechanisms, and pseudosubstrate regulation. Includes insights on αC helix, activation loop, and therapeutic implications (e.g., Gleevec binding).

Notes on 2002 Cell review discussing conformational plasticity of protein kinases, highlighting key structural elements, activation mechanisms, and pseudosubstrate regulation. Includes insights on αC helix, activation loop, and therapeutic implications (e.g., Gleevec binding).

Notes on 2008_PNAS paper revealing F-helix as a hub for regulatory and catalytic spine anchoring in protein kinases.

Notes on 2008_PNAS paper revealing F-helix as a hub for regulatory and catalytic spine anchoring in protein kinases.

The study redefines CASK as an active Mg²⁺-independent kinase that phosphorylates neurexin, integrating scaffolding and enzymatic functions, challenging its previous classification as a pseudokinase.

The study redefines CASK as an active Mg²⁺-independent kinase that phosphorylates neurexin, integrating scaffolding and enzymatic functions, challenging its previous classification as a pseudokinase.

Notes on the 2018 Trends in Biochemical Sciences review covering diverse mechanisms by which protein kinases achieve substrate specificity. The paper explores recognition motifs, docking interactions, adaptor-mediated recruitment, and multisite phosphorylation, highlighting how these shape signaling networks. (Still can’t like this paper — 23.03.23)

Notes on the 2018 Trends in Biochemical Sciences review covering diverse mechanisms by which protein kinases achieve substrate specificity. The paper explores recognition motifs, docking interactions, adaptor-mediated recruitment, and multisite phosphorylation, highlighting how these shape signaling networks. (Still can’t like this paper — 23.03.23)

Notes on the fundamental roles and mechanisms of protein kinase autophosphorylation, including examples from PKA, PKC, MLCK, RTKs, and others. Functional effects and evolutionary perspectives are also discussed.

Notes on the fundamental roles and mechanisms of protein kinase autophosphorylation, including examples from PKA, PKC, MLCK, RTKs, and others. Functional effects and evolutionary perspectives are also discussed.

Comprehensive review on how PKA holoenzyme assembly provides unique insights into kinase regulation, highlighting regulatory-catalytic subunit interactions, anchoring proteins, and macromolecular scaffolds.

Comprehensive review on how PKA holoenzyme assembly provides unique insights into kinase regulation, highlighting regulatory-catalytic subunit interactions, anchoring proteins, and macromolecular scaffolds.