Note on the discovery that the variable N-terminal domain of CDPK1 controls substrate specificity—offering a new mechanism to engineer signaling specificity in plants.
A 2006 JMB study presenting the crystal structure of Arabidopsis CDPK’s regulatory domain, revealing a domain-swapped dimer and an unexpected mechanism of calmodulin-like domain (CaM-LD) recognition, challenging classical calmodulin-target models.
A 2006 JMB study presenting the crystal structure of Arabidopsis CDPK’s regulatory domain, revealing a domain-swapped dimer and an unexpected mechanism of calmodulin-like domain (CaM-LD) recognition, challenging classical calmodulin-target models.
Comprehensive review of kalirin (KALRN) as a regulator of synaptic plasticity, its molecular domains and isoforms, and its emerging link to neurodevelopmental and neuropsychiatric disorders.
Comprehensive review of kalirin (KALRN) as a regulator of synaptic plasticity, its molecular domains and isoforms, and its emerging link to neurodevelopmental and neuropsychiatric disorders.
Notes on the 2023 eLife review analyzing protein kinase activation loop autophosphorylation. Discusses cis vs. trans mechanisms, dimerization, regulation, and the biochemical, structural, and kinetic evidence for these processes, while addressing the enigmatic nature of autophosphorylation.
Notes on the 2023 eLife review analyzing protein kinase activation loop autophosphorylation. Discusses cis vs. trans mechanisms, dimerization, regulation, and the biochemical, structural, and kinetic evidence for these processes, while addressing the enigmatic nature of autophosphorylation.
Comprehensive notes on the 2001 Chemical Reviews paper exploring the catalytic and kinetic mechanisms of protein kinases, with PKA as a model system. Covers substrate recognition, metal ion roles, phosphoryl transfer mechanisms, activation loop function, and rate-determining steps.
Comprehensive notes on the 2001 Chemical Reviews paper exploring the catalytic and kinetic mechanisms of protein kinases, with PKA as a model system. Covers substrate recognition, metal ion roles, phosphoryl transfer mechanisms, activation loop function, and rate-determining steps.
