Mechanisms

Notes on 2002 Cell review discussing conformational plasticity of protein kinases, highlighting key structural elements, activation mechanisms, and pseudosubstrate regulation. Includes insights on αC helix, activation loop, and therapeutic implications (e.g., Gleevec binding).

Notes on 2002 Cell review discussing conformational plasticity of protein kinases, highlighting key structural elements, activation mechanisms, and pseudosubstrate regulation. Includes insights on αC helix, activation loop, and therapeutic implications (e.g., Gleevec binding).