Notes on 2008 Biophysical Journal paper analyzing the thermodynamics of membrane insertion for an H-ras lipopeptide anchor (ANCH), highlighting the role of enthalpy-driven hydrophobic effects and conformational selection.
Notes on 2008 Biophysical Journal paper analyzing the thermodynamics of membrane insertion for an H-ras lipopeptide anchor (ANCH), highlighting the role of enthalpy-driven hydrophobic effects and conformational selection.
Notes on 2004 JMB paper exploring how preformed structural elements in intrinsically disordered proteins (IDPs) facilitate efficient binding and partner recognition.
Notes on 2004 JMB paper exploring how preformed structural elements in intrinsically disordered proteins (IDPs) facilitate efficient binding and partner recognition.
Notes on a 1999 Proteins review analyzing the conformational diversity of EF-hand motifs in calcium-binding proteins. Introduces Vector Geometry Mapping (VGM) to dissect helix movements beyond simple interhelical angles, and discusses functional implications of EF-hand plasticity.
Notes on a 1999 Proteins review analyzing the conformational diversity of EF-hand motifs in calcium-binding proteins. Introduces Vector Geometry Mapping (VGM) to dissect helix movements beyond simple interhelical angles, and discusses functional implications of EF-hand plasticity.
Notes on 2010 PNAS paper exploring how net charge per residue (NCPR) governs the balance between collapsed and extended conformations in intrinsically disordered proteins (IDPs), with implications for understanding IDP behavior and function.
Notes on 2010 PNAS paper exploring how net charge per residue (NCPR) governs the balance between collapsed and extended conformations in intrinsically disordered proteins (IDPs), with implications for understanding IDP behavior and function.
A modern view of allostery as an intrinsic property of protein dynamics, where conformational shifts, weak interactions, and energy landscapes enable regulation of function. Bridging classical models with cutting-edge experimental and theoretical insights, this review explores how proteins use dynamic ensembles and independent dynamic segments to facilitate signaling, folding, and ligand binding — redefining allostery beyond static views.
A modern view of allostery as an intrinsic property of protein dynamics, where conformational shifts, weak interactions, and energy landscapes enable regulation of function. Bridging classical models with cutting-edge experimental and theoretical insights, this review explores how proteins use dynamic ensembles and independent dynamic segments to facilitate signaling, folding, and ligand binding — redefining allostery beyond static views.
Comprehensive 2016 Frontiers review on the diverse binding mechanisms of intrinsically disordered proteins (IDPs), covering theory, simulations, and experimental insights into how disorder facilitates interaction dynamics, specificity, and versatility in cellular signaling.
Comprehensive 2016 Frontiers review on the diverse binding mechanisms of intrinsically disordered proteins (IDPs), covering theory, simulations, and experimental insights into how disorder facilitates interaction dynamics, specificity, and versatility in cellular signaling.
A 2010 Cell review expanding the classical models of protein-ligand binding to a dynamic landscape of conformational selection, induced fit, and independent dynamic segments. The paper highlights how ‘NOISE’—conformational fluctuations—can amplify signaling and regulate allosteric interactions, reshaping our understanding of binding and protein communication.
A 2010 Cell review expanding the classical models of protein-ligand binding to a dynamic landscape of conformational selection, induced fit, and independent dynamic segments. The paper highlights how ‘NOISE’—conformational fluctuations—can amplify signaling and regulate allosteric interactions, reshaping our understanding of binding and protein communication.
Notes on 2014 ACS paper introducing DFGmodel, a computational approach to predict kinase inactive structures for type-II inhibitor discovery. Includes insights on DFG-flip and kinase conformational analysis.
