Notes on 2014 ACS paper introducing DFGmodel, a computational approach to predict kinase inactive structures for type-II inhibitor discovery. Includes insights on DFG-flip and kinase conformational analysis.
Notes on the 1996 JMB paper introducing the Helical Lattice Superposition Model for analyzing helix-helix packing geometry in proteins. Explores mathematical formulations of optimal packing angles, comparing ‘knobs into holes’ and ‘ridges into grooves’ models, and provides insights into amino acid preferences and packing flexibility.
Notes on the 1996 JMB paper introducing the Helical Lattice Superposition Model for analyzing helix-helix packing geometry in proteins. Explores mathematical formulations of optimal packing angles, comparing ‘knobs into holes’ and ‘ridges into grooves’ models, and provides insights into amino acid preferences and packing flexibility.
Notes on a 2001 Journal of Molecular Biology paper revealing the crystal structure of Ca2+/CaM bound to a CaMKK-derived peptide, highlighting how calmodulin achieves conformational flexibility to accommodate diverse targets — offering a mechanistic basis for how CaM relieves autoinhibition of kinases like CaMKK and mediates calcium signal transduction.
Notes on a 2001 Journal of Molecular Biology paper revealing the crystal structure of Ca2+/CaM bound to a CaMKK-derived peptide, highlighting how calmodulin achieves conformational flexibility to accommodate diverse targets — offering a mechanistic basis for how CaM relieves autoinhibition of kinases like CaMKK and mediates calcium signal transduction.
A 2000 PROTEINS paper exploring the structural modeling of the calmodulin-like domain (CLD) of soybean CDPK-α, revealing unique domain features and potential intramolecular regulatory mechanisms based on homology modeling and experimental validation.
A 2000 PROTEINS paper exploring the structural modeling of the calmodulin-like domain (CLD) of soybean CDPK-α, revealing unique domain features and potential intramolecular regulatory mechanisms based on homology modeling and experimental validation.
