An in-depth review of CaMKK signaling, including structural, regulatory, and functional insights into its activation, downstream effects, and implications for disease.
Notes on 2004 Molecular Cell review analyzing how activation segment conformation regulates protein kinase activity, including insights into RD pocket, anchor residues, and alternative activation mechanisms.
Notes on 2004 Molecular Cell review analyzing how activation segment conformation regulates protein kinase activity, including insights into RD pocket, anchor residues, and alternative activation mechanisms.
Notes on 2012 FEBS Review about how phosphorylation controls protein stability via phosphodegrons and phospho-inhibited degrons, integrating ubiquitin-mediated degradation in cell cycle regulation.
Notes on 2012 FEBS Review about how phosphorylation controls protein stability via phosphodegrons and phospho-inhibited degrons, integrating ubiquitin-mediated degradation in cell cycle regulation.
Notes on 2024_ACS paper discussing the kinetic and structural principles of phosphorylation-driven protein switches and their biosensor applications.
Notes on 2024_ACS paper discussing the kinetic and structural principles of phosphorylation-driven protein switches and their biosensor applications.
Notes on 2006_PNAS paper exploring conserved structural mechanisms of kinase activation via surface comparison.
Notes on a 2014 PNAS paper analyzing PKA dynamics through community analysis.
Notes on 2010_PNAS study exploring how multisite phosphorylation of p53 modulates its interaction with CBP and transcriptional activation.
Notes on 2010_PNAS study exploring how multisite phosphorylation of p53 modulates its interaction with CBP and transcriptional activation.
Comprehensive notes on AKAPs as molecular scaffolds that regulate spatial and temporal signaling by anchoring PKA and other enzymes, enabling precise phosphorylation events in response to cellular stimuli.
Comprehensive notes on AKAPs as molecular scaffolds that regulate spatial and temporal signaling by anchoring PKA and other enzymes, enabling precise phosphorylation events in response to cellular stimuli.
The study redefines CASK as an active Mg²⁺-independent kinase that phosphorylates neurexin, integrating scaffolding and enzymatic functions, challenging its previous classification as a pseudokinase.
The study redefines CASK as an active Mg²⁺-independent kinase that phosphorylates neurexin, integrating scaffolding and enzymatic functions, challenging its previous classification as a pseudokinase.
