Notes on the 2018 Trends in Biochemical Sciences review covering diverse mechanisms by which protein kinases achieve substrate specificity. The paper explores recognition motifs, docking interactions, adaptor-mediated recruitment, and multisite phosphorylation, highlighting how these shape signaling networks. (Still can’t like this paper — 23.03.23)
Notes on the 2018 Trends in Biochemical Sciences review covering diverse mechanisms by which protein kinases achieve substrate specificity. The paper explores recognition motifs, docking interactions, adaptor-mediated recruitment, and multisite phosphorylation, highlighting how these shape signaling networks. (Still can’t like this paper — 23.03.23)
Notes on a 2002 JBC review dissecting CaMKII’s structure-function relationship, covering autoinhibition, isoform diversity, holoenzyme assembly, autophosphorylation, subunit exchange, and Ca2+/CaM frequency decoding — a foundational reference for understanding this multifunctional kinase as a calcium signal integrator.
Notes on a 2002 JBC review dissecting CaMKII’s structure-function relationship, covering autoinhibition, isoform diversity, holoenzyme assembly, autophosphorylation, subunit exchange, and Ca2+/CaM frequency decoding — a foundational reference for understanding this multifunctional kinase as a calcium signal integrator.
Notes on a 2004 Plant Cell paper mapping Arabidopsis plasma membrane phosphoproteins and phosphorylation sites.
Notes on a 2004 Plant Cell paper mapping Arabidopsis plasma membrane phosphoproteins and phosphorylation sites.
Notes on the fundamental roles and mechanisms of protein kinase autophosphorylation, including examples from PKA, PKC, MLCK, RTKs, and others. Functional effects and evolutionary perspectives are also discussed.
Notes on the fundamental roles and mechanisms of protein kinase autophosphorylation, including examples from PKA, PKC, MLCK, RTKs, and others. Functional effects and evolutionary perspectives are also discussed.
Notes on a 2015 Neuron paper revealing how CaMKII’s dual role as kinase and structural element regulates actin remodeling during synaptic plasticity, showing that autophosphorylation-mediated dissociation from F-actin provides a time window permissive for structural long-term potentiation (sLTP).
Notes on a 2015 Neuron paper revealing how CaMKII’s dual role as kinase and structural element regulates actin remodeling during synaptic plasticity, showing that autophosphorylation-mediated dissociation from F-actin provides a time window permissive for structural long-term potentiation (sLTP).
Notes on the mechanism by which PDK1 is activated via PIP3-mediated dimerization and trans-autophosphorylation, highlighting the role of PH domain autoinhibition, linker-mediated dimerization, and switch-like activation mechanisms.
Notes on the mechanism by which PDK1 is activated via PIP3-mediated dimerization and trans-autophosphorylation, highlighting the role of PH domain autoinhibition, linker-mediated dimerization, and switch-like activation mechanisms.
Overview of the plant-specific CDPK-SnRK superfamily, including CDPKs, CRKs, CCaMKs, SnRKs, and their Ca²⁺ regulatory mechanisms. Models of activation and functional diversity of Ca²⁺ decoding mechanisms are discussed.
Overview of the plant-specific CDPK-SnRK superfamily, including CDPKs, CRKs, CCaMKs, SnRKs, and their Ca²⁺ regulatory mechanisms. Models of activation and functional diversity of Ca²⁺ decoding mechanisms are discussed.
Notes on 1998 Cell review discussing kinase phosphoryl transfer mechanisms, conformational dynamics, cofactor roles, and binding motifs. Highlights the debate between associative (SN2) and dissociative (SN1) pathways, with structural evidence for both models.
