Comprehensive overview of Histidine Protein Kinases (HPKs), their role in two-component signaling systems across bacteria and non-animal eukaryotes, their domain structure, mechanism, and evolutionary significance.
Comprehensive overview of Histidine Protein Kinases (HPKs), their role in two-component signaling systems across bacteria and non-animal eukaryotes, their domain structure, mechanism, and evolutionary significance.
Notes on the 2023 eLife review analyzing protein kinase activation loop autophosphorylation. Discusses cis vs. trans mechanisms, dimerization, regulation, and the biochemical, structural, and kinetic evidence for these processes, while addressing the enigmatic nature of autophosphorylation.
Notes on the 2023 eLife review analyzing protein kinase activation loop autophosphorylation. Discusses cis vs. trans mechanisms, dimerization, regulation, and the biochemical, structural, and kinetic evidence for these processes, while addressing the enigmatic nature of autophosphorylation.
Comprehensive notes on the 2001 Chemical Reviews paper exploring the catalytic and kinetic mechanisms of protein kinases, with PKA as a model system. Covers substrate recognition, metal ion roles, phosphoryl transfer mechanisms, activation loop function, and rate-determining steps.
Comprehensive notes on the 2001 Chemical Reviews paper exploring the catalytic and kinetic mechanisms of protein kinases, with PKA as a model system. Covers substrate recognition, metal ion roles, phosphoryl transfer mechanisms, activation loop function, and rate-determining steps.
