PPIase

Notes on a 2002 Trends in Cell Biology review introducing phosphorylation-specific prolyl isomerization as a novel signaling mechanism. Pin1-mediated cis-trans switching of pSer/Thr-Pro motifs acts as a conformational timer for cellular signaling, impacting activity, interactions, and localization of key regulatory proteins.

Notes on a 2002 Trends in Cell Biology review introducing phosphorylation-specific prolyl isomerization as a novel signaling mechanism. Pin1-mediated cis-trans switching of pSer/Thr-Pro motifs acts as a conformational timer for cellular signaling, impacting activity, interactions, and localization of key regulatory proteins.