A conceptual leap in understanding protein folding, showing how water molecules and molecular chaperones act as weak, transient links that smooth energy landscapes and prevent conformational traps. This paper connects protein folding, dynamic networks, and game theory, offering a new way to see how folding and interaction landscapes are managed in crowded cellular environments.
A conceptual leap in understanding protein folding, showing how water molecules and molecular chaperones act as weak, transient links that smooth energy landscapes and prevent conformational traps. This paper connects protein folding, dynamic networks, and game theory, offering a new way to see how folding and interaction landscapes are managed in crowded cellular environments.
Notes on the 1996 JMB paper introducing the Helical Lattice Superposition Model for analyzing helix-helix packing geometry in proteins. Explores mathematical formulations of optimal packing angles, comparing ‘knobs into holes’ and ‘ridges into grooves’ models, and provides insights into amino acid preferences and packing flexibility.
Notes on the 1996 JMB paper introducing the Helical Lattice Superposition Model for analyzing helix-helix packing geometry in proteins. Explores mathematical formulations of optimal packing angles, comparing ‘knobs into holes’ and ‘ridges into grooves’ models, and provides insights into amino acid preferences and packing flexibility.
