Receptor Tyrosine Kinase

An elegant dissection of how EGFR activation depends on conformational coupling across the plasma membrane, revealing that ligand binding, transmembrane helix dimerization, and juxtamembrane interactions are essential to overcoming membrane-imposed inhibition and stabilizing the active kinase dimer.

A study demonstrating that EGFR activation is not tightly coupled to specific transmembrane dimerization interfaces, suggesting a loose linkage between extracellular ligand binding and intracellular kinase activation.

A study demonstrating that EGFR activation is not tightly coupled to specific transmembrane dimerization interfaces, suggesting a loose linkage between extracellular ligand binding and intracellular kinase activation.