Notes on 2006 JMB review detailing EF-hand protein diversity, mechanisms of Ca2+ binding, and conformational change. Highlights the EFbeta-scaffold model and structural determinants of domain opening in calcium-binding proteins.
Notes on 2006 JMB review detailing EF-hand protein diversity, mechanisms of Ca2+ binding, and conformational change. Highlights the EFbeta-scaffold model and structural determinants of domain opening in calcium-binding proteins.
Comprehensive notes on AKAPs as molecular scaffolds that regulate spatial and temporal signaling by anchoring PKA and other enzymes, enabling precise phosphorylation events in response to cellular stimuli.
Comprehensive notes on AKAPs as molecular scaffolds that regulate spatial and temporal signaling by anchoring PKA and other enzymes, enabling precise phosphorylation events in response to cellular stimuli.
Notes on the 1999 Cell paper describing crystal structures of spectrin repeats and introducing two models for spectrin’s flexibility: conformational rearrangement and linker bending. Provides insights into spectrin’s role as a flexible cytoskeletal scaffold.
Notes on the 1999 Cell paper describing crystal structures of spectrin repeats and introducing two models for spectrin’s flexibility: conformational rearrangement and linker bending. Provides insights into spectrin’s role as a flexible cytoskeletal scaffold.
Comprehensive review on how PKA holoenzyme assembly provides unique insights into kinase regulation, highlighting regulatory-catalytic subunit interactions, anchoring proteins, and macromolecular scaffolds.
Comprehensive review on how PKA holoenzyme assembly provides unique insights into kinase regulation, highlighting regulatory-catalytic subunit interactions, anchoring proteins, and macromolecular scaffolds.
