Sequence Analysis

Notes on the foundational 1991 Science paper introducing a sequence-based method to predict coiled-coil domains. This paper outlines a statistical framework using heptad repeat patterns, Gaussian distributions, and sliding windows, uncovering over 200 proteins in GenBank with potential coiled-coil motifs.

Notes on the foundational 1991 Science paper introducing a sequence-based method to predict coiled-coil domains. This paper outlines a statistical framework using heptad repeat patterns, Gaussian distributions, and sliding windows, uncovering over 200 proteins in GenBank with potential coiled-coil motifs.