Notes on a 2002 Trends in Cell Biology review introducing phosphorylation-specific prolyl isomerization as a novel signaling mechanism. Pin1-mediated cis-trans switching of pSer/Thr-Pro motifs acts as a conformational timer for cellular signaling, impacting activity, interactions, and localization of key regulatory proteins.
Notes on a 2002 Trends in Cell Biology review introducing phosphorylation-specific prolyl isomerization as a novel signaling mechanism. Pin1-mediated cis-trans switching of pSer/Thr-Pro motifs acts as a conformational timer for cellular signaling, impacting activity, interactions, and localization of key regulatory proteins.
Comprehensive notes on AKAPs as molecular scaffolds that regulate spatial and temporal signaling by anchoring PKA and other enzymes, enabling precise phosphorylation events in response to cellular stimuli.
Comprehensive notes on AKAPs as molecular scaffolds that regulate spatial and temporal signaling by anchoring PKA and other enzymes, enabling precise phosphorylation events in response to cellular stimuli.
